| 1 | Chris Wondolowski | San Jose Earthquakes | 18 | 9 | 2 | 0 |
| 2 | Edson Buddle | L.A. Galaxy | 17 | 11 | 0 | 0 |
| 3 | Dwayne De Rosario | Toronto FC | 15 | 4 | 1 | 0 |
| 4 | Omar Cummings | Colorado Rapids | 14 | 7 | 0 | 0 |
| 4 | Sebastien Le Toux | Philadelphia Union | 14 | 4 | 2 | 0 |
| 6 | Conor Casey | Colorado Rapids | 13 | 4 | 3 | 0 |
| 6 | Juan Pablo Angel | New York Red Bulls | 13 | 1 | 3 | 0 |
| 8 | Alvaro Saborio | Real Salt Lake | 12 | 2 | 2 | 0 |
| 9 | Jeff Cunningham | FC Dallas | 11 | 4 | 3 | 0 |
| 10 | Kei Kamara | Sporting Kansas City | 10 | 5 | 0 | 0 |
| 10 | Fredy Montero | Seattle Sounders FC | 10 | 4 | 0 | 0 |
| 10 | Steve Zakuani | Seattle Sounders FC | 10 | 5 | 0 | 0 |
| 13 | Schelotto Guillermo Barros | Columbus Crew | 9 | 6 | 4 | 0 |
| 13 | Justin Braun | CD Chivas USA | 9 | 5 | 0 | 0 |
| 15 | David Ferreira | FC Dallas | 8 | 3 | 3 | 0 |
| 16 | Javier Damian Morales | Real Salt Lake | 7 | 4 | 1 | 0 |
| 16 | Marco Pappa | Chicago Fire | 7 | 3 | 0 | 0 |
| 16 | Sam Cronin | Toronto FC | 1 | 0 | 1 | 0 |
| 16 | Landon Donovan | L.A. Galaxy | 7 | 0 | 1 | 0 |
| 16 | Chad Barrett | Toronto FC | 7 | 2 | 0 | 0 |
| 16 | Danny Mwanga | Philadelphia Union | 7 | 2 | 0 | 0 |
| 16 | Brian Ching | Houston Dynamo | 7 | 3 | 0 | 0 |
| 22 | Edgar Fabian Espindola | Real Salt Lake | 6 | 3 | 0 | 0 |
| 22 | Davy Arnaud | Sporting Kansas City | 6 | 3 | 1 | 0 |
| 22 | Brian McBride | Chicago Fire | 6 | 1 | 1 | 0 |
| 22 | Jesus Andres Padilla | CD Chivas USA | 6 | 2 | 0 | 0 |
| 22 | Marko Perovic | New England Rev. | 6 | 3 | 0 | 0 |
| 27 | Brad Davis | Houston Dynamo | 5 | 1 | 1 | 0 |
| 27 | Zack Schilawski | New England Rev. | 5 | 1 | 0 | 0 |
| 27 | Dominic Oduro | Houston Dynamo | 5 | 0 | 0 | 0 |
| 27 | Baggio Husidic | Chicago Fire | 5 | 3 | 0 | 0 |
| 27 | Maicon Santos | Toronto FC | 5 | 1 | 0 | 0 |
| 27 | Steven Lenhart | Columbus Crew | 5 | 1 | 0 | 0 |
| 27 | Danny Allsopp | DC United | 5 | 3 | 0 | 0 |
| 27 | Robbie Findley | Real Salt Lake | 5 | 2 | 1 | 0 |
| 27 | Brek Shea | FC Dallas | 5 | 4 | 0 | 0 |
| 27 | Emilio Renteria | Columbus Crew | 5 | 3 | 0 | 0 |
| 27 | Andy Najar | DC United | 5 | 2 | 0 | 0 |
| 27 | Teal Bunbury | Sporting Kansas City | 5 | 2 | 0 | 0 |
| 27 | Milton Fabian Rodriguez Suarez | FC Dallas | 5 | 2 | 0 | 0 |
| 27 | Birahim Diop | Sporting Kansas City | 5 | 2 | 0 | 0 |
| 27 | Dane Richards | New York Red Bulls | 5 | 4 | 0 | 0 |
| 27 | Blaise N´Kufo | Seattle Sounders FC | 5 | 2 | 0 | 0 |
| 35 | Frankie Hejduk | Columbus Crew | 1 | 1 | 0 | 0 |
| 43 | Atiba Harris | FC Dallas | 4 | 1 | 0 | 0 |
| 43 | Kenny Mansally | New England Rev. | 4 | 1 | 0 | 0 |
| 43 | Jeff Larentowicz | Colorado Rapids | 4 | 2 | 0 | 0 |
| 43 | Mehdi Ballouchy | New York Red Bulls | 4 | 3 | 1 | 0 |
| 43 | Jovan Kirovski | L.A. Galaxy | 4 | 2 | 0 | 0 |
| 43 | Helbert Frederico Carreiro da Silva Fred | Philadelphia Union | 4 | 2 | 0 | 0 |
USA | Major League Soccer | 2010
